Quantumzyme Receives Patent for Development of Green Catalyst in India
Bangalore, March 27, 2023 : Quantumzyme, a biotransformation company, focused on clean and green chemistr y has recently been granted a patent for the transaminase enzyme by applying its revolutionary technology QZy me WorkbenchTM in India. The patent was granted for creating a green catalyst for one of the world’s most sign ificant chemical reactions, which can be useful for pharmaceutical and agricultural industries. The groundbreak ing “QZyme WorkbenchTM” technology can handle a wide range of important aspects of protein modeling and engineering, including structural refinement, ligand docking, conformational sampling, estimating substrate bin ding affinity, modeling catalytic reactions, identifying mutable hotspots, and further hotspot optimization.
With diabetes quickly becoming a lifestyle disease in India, with over 74 million active patients and a big commu nity that remains undiagnosed. The introduction of more affordable drugs is expected to increase volumes due t o improved accessibility. Sitagliptin (Januvia) had its last days in India in the year 2022 and while Sitagliptin is a n ewer molecule to the Indian market, the cost of therapy is anticipated to fall from Rs.45 per day charged by Mer ck to Rs.8-18 per day charged by generic competitors.
Mr. Naveen Kulkarni, CEO, Quantumzyme reports, “Given the current patent and trademark landscape, this is cr ucial and encouraging for our company. We only hope to create more resourceful green catalysts and develop be tter technologies to justify our work as a company to provide more efficiently to the industries in need.”
Quantumzyme discovered and optimized a new biocatalytic synthetic route for enantiopure chiral amine, a criti cal intermediate in the synthesis of Sitagliptin. This approach offers significant benefits to Indian generic players by reducing their dependency on China, where the key intermediate is currently imported, and by making the ke y intermediate available locally at competitive prices, enabling generic players to reduce costs significantly and make the drug more affordable, where the key intermediate is currently imported; second, the key intermediate will be made available locally at competitive prices, allowing generic players to significantly reduce costs and ma ke the drug affordable. Transaminase reactions have a crucial role to play in the API and fertilizer/agriculture ind ustries by providing a means to efficiently produce essential molecules such as chiral amines and amino acids. Th e technology has the potential to enhance plant growth and yield by synthesizing amino acid-based plant growth regulators.
Because of its essential synthesis from sustainable sources, advances in green chemistry are inextricably linked to biocatalysts. Green catalysts have the ability to catalyze various chemical reactions, making them an import ant option to environmentally hazardous chemical mechanisms.
About Quantumzyme: Quantumzyme is a biotransformation company, focused on clean and green chemistry. It focuses on research to enhance enzyme activity, selectivity and specificity by applying novel quantum mechan ic s, molecular modeling and engineering approaches that might help the world attain sustainability and save res o urces efficiently. To mitigate the challenges, Quantumzyme has developed an in silico protocol known as the QZ yme WorkbenchTM that is capable of tackling several important aspects of protein modeling and engineering.
